Author Topic: Covid Culture (was Outbreak Culture)  (Read 106494 times)

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Offline waldo

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Re: Covid Culture (was Outbreak Culture)
« Reply #2850 on: February 04, 2021, 01:31:49 am »
Novavax and Canada Reach Agreement in Principle to Acquire Novavax’ COVID-19 Vaccine --- Canadian government to purchase up to 76 million doses of NVX-CoV2373

{Novavax has signed similar deals with the United Kingdom, India, the Czech Republic, South Africa and Japan to supply doses of the potential vaccine.}

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NVX-CoV2373 is currently in multiple Phase 2 clinical trials. The Phase 2 portion of the Phase 1/2 clinical trial to evaluate the safety and immunogenicity of NVX-CoV2373 began in August in the United States and Australia, and expands on the age range of the Phase 1 portion by including older adults 60-84 years of age as approximately 50 percent of the trial population. Secondary objectives include preliminary evaluation of efficacy. In addition, a Phase 2b clinical trial to assess efficacy began in South Africa in August.

About NVX-CoV2373 - NVX‑CoV2373 is a vaccine candidate engineered from the genetic sequence of SARS‑CoV‑2, the virus that causes COVID-19 disease. NVX‑CoV2373 was created using Novavax’ recombinant nanoparticle technology to generate antigen derived from the coronavirus spike (S) protein and contains Novavax’ patented saponin-based Matrix-M™ adjuvant to enhance the immune response and stimulate high levels of neutralizing antibodies. In preclinical trials, NVX‑CoV2373 demonstrated indication of antibodies that block binding of spike protein to receptors targeted by the virus, a critical aspect for effective vaccine protection. In its Phase 1 data of the Phase 1/2 clinical trial, NVX‑CoV2373 was generally well-tolerated and elicited robust antibody responses numerically superior to that seen in human convalescent sera. Phase 2 clinical trials began in August. Novavax has secured $2 billion in funding for its global coronavirus vaccine program, including up to $388 million in funding from the Coalition for Epidemic Preparedness Innovations (CEPI).

About Matrix-M™ - Novavax’ patented saponin-based Matrix-M™ adjuvant has demonstrated a potent and well-tolerated effect by stimulating the entry of antigen-presenting cells into the injection site and enhancing antigen presentation in local lymph nodes, boosting immune response.
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Actually, with multiple variants, it's likely that the oldest tech, used by Novavax holds the long term key to this. mRNA vaccines can only have so many proteins added to it before it becomes too much for the body to take. That makes it less suited to the long term management of multiple variants.
Novavax has now submitted their candidate for approval. It uses the same type of technology as the flu vaccine, and probably holds the most promise for long term control of SARS-COV-2.


Canada signs deal with Novavax to make its COVID-19 vaccine at new Montreal facility


Offline Michael Hardner

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Offline wilber

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"Never trust a man without a single redeeming vice" WSC
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Offline Squidward von Squidderson

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Re: Covid Culture (was Outbreak Culture)
« Reply #2853 on: February 04, 2021, 02:04:53 pm »
https://www.cbc.ca/amp/1.5900853

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Maj.-Gen. Dany Fortin, the military commander leading vaccine logistics at the Public Health Agency of Canada (PHAC), said today Canada doesn't know how many Moderna doses will arrive in the weeks ahead and the company hasn't said why it has reduced shipments to our country.

Speaking to reporters at a public health briefing, Fortin said 180,000 Moderna doses arrived this morning but the government has no "visibility" on how many more shots will be delivered this month and next.

Before sitting down to a press conference, maybe figure this sh!t out?   That would be a good first step.

This is not good.
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Offline JMT

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Re: Covid Culture (was Outbreak Culture)
« Reply #2854 on: February 04, 2021, 03:08:15 pm »
https://www.cbc.ca/amp/1.5900853

Before sitting down to a press conference, maybe figure this sh!t out?   That would be a good first step.

This is not good.

Moderna is unable to tell them how many. They're not sure how long it's going to take their factory to work through the kinks. Here's what their subcontractor, Lonza, said on the 28th:

https://twitter.com/paulvieira/status/1357427865877434372?s=20

Offline BC_cheque

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Re: Covid Culture (was Outbreak Culture)
« Reply #2855 on: February 04, 2021, 03:53:39 pm »
@waldo

What did you think of this report ?

https://thetyee.ca/Analysis/2021/02/03/Experts-Rated-98-Nations-Handling-COVID-Canada-61st/

One thing I think complicates things in Canada is that healthcare is a provincial matter.  We had different provinces with different closures and rules and yet freedom of movement is a federal issue, as BC came to find out when trying to ban travel from other provinces.

The countries that handled the virus well from the start had a strong centalized response.  That's where the 'fault' lays with the federal government, but OTOH, I know too many idiots would be crying foul about JT acting like a dictator if he'd taken a stronger approach.

We keep looking at the US in shock and feeling accomplished but we did terribly in the grander scheme of things because of our decentralized approach.
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Offline Queefer Sutherland

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Re: Covid Culture (was Outbreak Culture)
« Reply #2856 on: February 04, 2021, 03:58:20 pm »
Every country in the world needs to plow money into Moderna and Pfizer and every engineer and construction worker needs to travel to these countries, build vaccine facilities as far as the eye can see, and then get scientists or whoever pumping out these vaccines like they're candy so that every country is drowning up to their eyeballs in needles.  Figure out the compensation scheme later.  And then when the pandemic is over turn these facilities into arcades because I miss arcades.
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Offline wilber

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Re: Covid Culture (was Outbreak Culture)
« Reply #2857 on: February 04, 2021, 04:05:31 pm »
One thing I think complicates things in Canada is that healthcare is a provincial matter.  We had different provinces with different closures and rules and yet freedom of movement is a federal issue, as BC came to find out when trying to ban travel from other provinces.

The countries that handled the virus well from the start had a strong centalized response.  That's where the 'fault' lays with the federal government, but OTOH, I know too many idiots would be crying foul about JT acting like a dictator if he'd taken a stronger approach.

We keep looking at the US in shock and feeling accomplished but we did terribly in the grander scheme of things because of our decentralized approach.

I don't know. Australia's system is similar to ours and they are #8.
"Never trust a man without a single redeeming vice" WSC

Offline BC_cheque

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Re: Covid Culture (was Outbreak Culture)
« Reply #2858 on: February 04, 2021, 04:08:09 pm »
I don't know. Australia's system is similar to ours and they are #8.

They had a centralized response though even though their healthcare is decentralized. 

Trudeau could've done it too if he really wanted, but as always the Liberal Party tries to please everyone.
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Offline wilber

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Re: Covid Culture (was Outbreak Culture)
« Reply #2859 on: February 04, 2021, 04:15:36 pm »
They had a centralized response though even though their healthcare is decentralized. 

Trudeau could've done it too if he really wanted, but as always the Liberal Party tries to please everyone.

They do have a geographical advantage as well. Our proximity to the US is both a blessing and a curse.
They continue to come down hard and heavy on any outbreaks and are reaping the benefit. I'm envious watching the maskless crowds wandering around the Australian Open this week.
"Never trust a man without a single redeeming vice" WSC
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Offline Squidward von Squidderson

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Re: Covid Culture (was Outbreak Culture)
« Reply #2860 on: February 04, 2021, 04:34:00 pm »
They had a centralized response though even though their healthcare is decentralized. 

Trudeau could've done it too if he really wanted, but as always the Liberal Party tries to please everyone.

I think you’re right...  the Feds could have said “these are the standards you must meet to get federal funding so you can keep Canadians safe” and then let the idiots like Kenney and Ford **** and moan...     We would have been far better off with a centralized, and strict, approach to COVID.

I wouldn’t give them a failing grade....   maybe a C-.   What they have done has been OK, but a centralized response for a worldwide pandemic was needed.

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Offline JMT

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Re: Covid Culture (was Outbreak Culture)
« Reply #2861 on: February 04, 2021, 05:11:39 pm »
They had a centralized response though even though their healthcare is decentralized. 

Trudeau could've done it too if he really wanted, but as always the Liberal Party tries to please everyone.

Most of the powers Trudeau needed would require the use of the Emergencies Act. The provinces must be meaningfully consulted. They were. Their response: https://regina.ctvnews.ca/neither-necessary-nor-advisable-premiers-tell-pm-there-is-no-need-for-emergencies-act-1.4897798

Offline Squidward von Squidderson

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Re: Covid Culture (was Outbreak Culture)
« Reply #2862 on: February 04, 2021, 05:32:56 pm »
Most of the powers Trudeau needed would require the use of the Emergencies Act. The provinces must be meaningfully consulted. They were. Their response: https://regina.ctvnews.ca/neither-necessary-nor-advisable-premiers-tell-pm-there-is-no-need-for-emergencies-act-1.4897798

Meaningfully consulted does not mean they must give their consent. 
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Offline JMT

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Re: Covid Culture (was Outbreak Culture)
« Reply #2863 on: February 04, 2021, 07:12:01 pm »
Meaningfully consulted does not mean they must give their consent.

Technically true, but the act is very narrow. Provinces must lack the capacity to respond, or must have exhausted their capacity. It's also been pointed out by some constitutional experts that that meaningful consent, owing the court definitions, means that all issues that the provinces raise must be addressed. Trying to impose your will on provincial jurisdiction without their cooperation would be nearly impossible due to the structure of the Constitution.

How do I know this? Because I made the same arguments that you're making for using the Emergencies Act.

Offline wilber

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Re: Covid Culture (was Outbreak Culture)
« Reply #2864 on: February 04, 2021, 07:55:35 pm »
Technically true, but the act is very narrow. Provinces must lack the capacity to respond, or must have exhausted their capacity. It's also been pointed out by some constitutional experts that that meaningful consent, owing the court definitions, means that all issues that the provinces raise must be addressed. Trying to impose your will on provincial jurisdiction without their cooperation would be nearly impossible due to the structure of the Constitution.

How do I know this? Because I made the same arguments that you're making for using the Emergencies Act.

If that's the case, the act isn't worth the paper is written on.
"Never trust a man without a single redeeming vice" WSC